Understanding the Basis of Complex Behaviour

Longitudinal hippocampal volumetric changes in mice following brain infarction

VH Brait, DK Wright, M Nategh, A Oman, WT Syeda, CM Ermine, KR O’Brien, E Werden, L Churilov, LA Johnston, LH Thompson, J Nithianantharajah, KA Jackman, A Brodtmann

2021-12-01

Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cogniti..

Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity

JK Luo, H Melland, J Nithianantharajah, SL Gordon

2021-10-08

Fast, high-fidelity neurotransmission and synaptic efficacy requires tightly regulated coordination of pre- and postsynaptic compa..

MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice

M Watts, G Williams, J Lu, J Nithianantharajah, C Claudianos

2021-04-01

MicroRNAs are known to be critical regulators of neuronal plasticity. The highly conserved, hypoxia-regulated microRNA-210 (miR-21..

A molecular insight into the dissociable regulation of associative learning and motivation by the synaptic protein neuroligin-1

J Luo, JM Tan, J Nithianantharajah

2020-09-14

BACKGROUND: In a changing environment, a challenge for the brain is to flexibly guide adaptive behavior towards survival. Complex ..

Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics

JL Silverman, J Nithianantharajah, A Der-Avakian, JW Young, SJ Sukoff Rizzo

2020-09-01

MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV interneurons or forebrain pyramidal cells

E Sokolenko, J Nithianantharajah, NC Jones

2020-07-01

NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: ..

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse

AJL Leembruggen, GK Balasuriya, J Zhang, S Schokman, K Swiderski, JC Bornstein, J Nithianantharajah, EL Hill-Yardin

2020-05-01

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..

Altered Caecal Neuroimmune Interactions in the Neuroligin-3R451C Mouse Model of Autism

SS Sharna, GK Balasuriya, S Hosie, J Nithianantharajah, AE Franks, EL Hill-Yardin

2020-04-09

The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via bidirectional neuroimmune int..

Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference

Rebecca HC Norris, Leonid Churilov, Anthony J Hannan, Jess Nithianantharajah

2019-01-01

Cognitive dysfunction including disrupted behavioral flexibility is central to neurodevelopmental disorders such as Autism Spectru..

Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations

J Luo, RH Norris, SL Gordon, J Nithianantharajah

2018-06-08

The genomic revolution has begun to unveil the enormous complexity and heterogeneity of the genetic basis of neurodevelopmental di..

Hypoxia-induced MicroRNA-210 targets neurodegenerative pathways

ME Watts, SM Williams, J Nithianantharajah, C Claudianos

2018-03-27

Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditi..

Local NMDA receptor hypofunction evokes generalized effects on gamma and high-frequency oscillations and behavior

J Lee, MR Hudson, TJ O'Brien, J Nithianantharajah, NC Jones

2017-09-01

The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathop..

Using Animal Models to Study the Role of the Gut–Brain Axis in Autism

J Nithianantharajah, GK Balasuriya, AE Franks, EL Hill-Yardin

2017-06-01

Purpose of Review: Individuals with autism spectrum disorders (ASD) commonly also suffer from gastrointestinal (GI) dysfunction; h..